South Africa lost 4 wickets for 7 runs in the 1st 9 overs, but resumed on one thirty six-four in search of a distant four hundred and sixteen.
Moeen Ali gets rid of danger man AB de Villiers with the 3rd ball and Steven Finn completed by 4-42 as the hosts were all out before lunch for 174.
In Cape Town, the 2nd of the four-match series begins, on Saturday.
Alastair Cook, captain of the England said that the lads had played really nice. It was not easy to bat but Nick Compton played in such a way, after getting out of Test cricket, he was so great in the 1st innings to give them all a platform, and then they bowled so well in both innings.
The bowlers mixed their speed and were constant. It was their 1st away win after a long time so they will enjoy this victory but they also know about the strong side of South Africa.
Graeme Swann, former England spinner described the De Villiers wicket as solid for Moeen, because he has to go nervously to the bed instead people expecting him to make the game.
After all, such performance, in his next over, Moeen then gave another wicket maiden, which had drawn Temba Bavuma out of his crease.
All of the end, it was Moeen, who ended with 7-116 match figures, so he named as the man of the match.